منابع مشابه
Mitochondria and regulated tyrosine nitration.
The conditions of the cellular microenvironment in complex multicellular organisms fluctuate, enforcing permanent adaptation of cells at multiple regulatory levels. Covalent post-translational modifications of proteins provide the short-term response tools for cellular adjustment and growing evidence supports the possibility that protein tyrosine nitration is part of this cellular toolkit and n...
متن کاملProtein nitration in cardiovascular diseases.
There is growing evidence that cardiovascular disease is associated with progressive changes in the production of free radicals and radical-derived reactive species. These intermediates react with all major cellular constituents and may serve several physiological and pathophysiological functions. The nitration of protein tyrosine residues has been used as a footprint for in vivo production of ...
متن کاملNitration of naphthalene and remarks on the mechanism of electrophilic aromatic nitration.
Naphthalene was nitrated with a variety of nitrating agents. Comparison of data with Perrin's electrochemical nitration [Perrin, C. L. (1977) J. Am. Chem. Soc. 99, 5516-5518] shows that nitration of naphthalene gives an alpha-nitronaphthalene to beta-nitronaphthalene ratio that varies between 9 and 29 and is thus not constant. Perrin's data, therefore, are considered to be inconclusive evidence...
متن کاملTransmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications.
We have shown previously that peroxynitrite-induced nitration of a hydrophobic tyrosyl probe is greater than that of tyrosine in the aqueous phase (Zhang, H., Joseph, J., Feix, J., Hogg, N., and Kalyanaraman, B. (2001) Biochemistry 40, 7675-7686). In this study, we have tested the hypothesis that the extent of tyrosine nitration depends on the intramembrane location of tyrosyl probes and on the...
متن کامل-Synuclein Phosphorylation and Nitration in Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting six million people worldwide. PD results from the specific loss of substantia nigra dopaminergic neurons. Aggregation of one protein, -synuclein, is characteristic of PD. This aggregation is thought to be a critical step in the etiology of the disease. While the molecular mechanism of -synuclein aggregation ...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1951
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.9.5_76